Журнал «Здоровье ребенка» (62) 2015. Тематический выпуск "Детская гастроэнтерология"

Introduction. In 2005. World Gastroenterology Organisation, it was noted that 1% of the world's population suffer from celiac disease and can not eat cereals such as wheat, rye, barley and oats, as well as foods that contain them. Celiac disease - is one of the most common genetic disease that affects the small intestine and leads to malabsorption of nutrients from food.

Based on the above, the purpose of our study was to investigate the problems of drugs celiac disease based on pharmaceutical law.

Materials and methods. Materials were scientific sources on the prevalence of celiac disease in the world, studied and summarized recipes of extemporaneous formulations, which used for the treatment of dermatological diseases. To achieve this goal used legal and documentary analysis.

The results of the study. Celiac disease (or gluten enteropathy) is a chronic autoimmune disease that affects the digestive tract of genetically predisposed individuals who have an intolerance to the basic protein cereals – gluten. The major symptoms of celiac disease – polymorphic disorders of the gastrointestinal tract, but in 65-85% of cases there extraintestinal manifestations which displace the aforementioned symptoms. These manifestations of dermatitis herpetiformis of the Duhring refers to the typical of cutaneous manifestations of celiac disease, as well as various types of eczema. Found that systemic treatment of cutaneous manifestations of celiac disease involves the use of drugs sulfone series - diafenilsulfon (dapsone, Avlosulfon, Dimotsifon, Diutsifon), but with little effect of the drug is used glucocorticoid medications for regular use (prednisolone, dexamethasone, triamcinolone). Carried out by the research showed that the number of sulfone drugs, namely diafenilsulfon, Ukraine does not have and none of the above drugs in the country is not registered. In Ukraine, you can buy only the drug dapsone, and only through a network of online pharmacies. After examining the range of medicines that are used in the treatment of cutaneous manifestations of celiac disease (namely, preparations for external use), the authors found that the pharmaceutical market in Ukraine is not enough finished drugs that could fully satisfy the need for them to solve the problem of individual patient intolerance of components. Therefore, the authors drew attention to the extemporaneous preparations (EP), which combine in a single dosage form different active pharmaceutical ingredients (APIs), taking into account the individual characteristics of each patient (age, sex, body weight, concomitant diseases, etc.). After considering the range of extemporaneous compounding the authors selected and offered effective and accessible (subject to the availability of the API) extemporaneous recipe, which includes sulfur (showing keratolytic and antiparasitic action); salicylic acid (antiseptic); resorcinol (antibacterial and antifungal agent); streptocid (antimicrobial agent); boric acid (preservative exhibiting fungistatic action); prednisolone (hormonal agent, has anti-allergic, and protivovospaltelnym desensitizing effect); zinc sulfate (antiseptic). In addition, the authors developed a manual for medical use and defined control regime of the extemporaneous formulation.

Conclusions. The authors studied the problem of drugs with celiac disease based on the pharmaceutical law. Offered an alternative EP, which can used in complex therapy of cutaneous manifestations of celiac disease, defined by its mode of control and designed instruction for medical use. Implementation of the proposed extemporaneous prescriptions in the practice of healthcare facilities will expand the range of drugs used for the treatment of cutaneous manifestations of celiac disease, improve the quality of health-pharmaceutical care, taking into account the individual characteristics of each patient, as well as provide the opportunity to organize the order of treatment with EP on the stage of prescription, manufacturing and the supply of pharmacies in accordance with the requirements of the medical and pharmaceutical legislation.